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Showing 1 to 12 of 155 entries
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An Influenza Virus M2 Protein Specific Chimeric Antigen Receptor Modulates Influenza A/WSN/33 H1N1 Infection In Vivo.

The open virology journal

Talbot SJ, Blair NF, McGill N, Ligertwood Y, Dutia BM, Johannessen I.
PMID: 23493233
Open Virol J. 2013;7:28-36. doi: 10.2174/1874357901307010028. Epub 2013 Feb 25.

A potential target for the development of universal vaccine strategies against Influenza A is the M2 protein - a membrane protein with a highly conserved extracellular domain. In this study we developed engineered T-cell receptors, by fusing M2-specific antibody...

Development of an Ad5H3 Chimera Using the "Antigen Capsid-Incorporation" Strategy for an Alternative Vaccination Approach.

The open virology journal

Gu L, Icyuz M, Krendelchtchikova V, Krendelchtchikov A, Johnston AE, Matthews QL.
PMID: 27335626
Open Virol J. 2016 Apr 26;10:10-20. doi: 10.2174/1874357901610010010. eCollection 2016.

BACKGROUND: Adenovirus type 5 (Ad5) achieved success as a conventional transgene vaccine vector in preclinical trials, however; achieved poor efficiency in some of the clinical trials, due to the major hurdle associated with Ad5 pre-existing immunity (PEI) in the...

Determining the Actual Prevalence of Hepatitis B in Khyber Pakhtunkhwa-Pakistan: A Meta-Analysis.

The open virology journal

Khan NU, Zalan A, Petruzziello A, Ud Din I, Haq F, Hayat Y.
PMID: 29576813
Open Virol J. 2018 Feb 28;12:33-41. doi: 10.2174/1874357901812010033. eCollection 2018.

BACKGROUND: Hepatitis B is considered the most dangerous among the five types of Hepatitis, as it is clinically asymptomatic. It can silently damage the liver over many years without being diagnosed. Hepatitis B is one of the top risks...

Viruses Causing Hemorrhagic Fever. Safety Laboratory Procedures.

The open virology journal

Cobo F.
PMID: 27014378
Open Virol J. 2016 Jan 15;10:1-9. doi: 10.2174/1874357901610010001. eCollection 2016.

Viral hemorrhagic fevers are diseases caused by viruses which belong to different families, many of them causing severe diseases. These viruses may produce different symptomatology together with a severe multisystem syndrome, and the final result might be the production...

Molecular Detection of Human Cytomegalovirus (HCMV) Among Infants with Congenital Anomalies in Khartoum State, Sudan.

The open virology journal

Ebrahim MG, Ali AS, Mustafa MO, Musa DF, El Hussein AR, Elkhidir IM, Enan KA.
PMID: 26862356
Open Virol J. 2015 Dec 10;9:38-41. doi: 10.2174/1874357901509010038. eCollection 2015.

Human Cytomegalovirus (HCMV) infection still represents the most common potentially serious viral complication in humans and is a major cause of congenital anomalies in infants. This study is aimed to detect HCMV in infants with congenital anomalies. Study subjects...

Analysis of HIV Protease Killing Through Caspase 8 Reveals a Novel Interaction Between Caspase 8 and Mitochondria.

The open virology journal

Algeciras-Schimnich A, Belzacq-Casagrande AS, Bren GD, Nie Z, Taylor JA, Rizza SA, Brenner C, Badley AD.
PMID: 18818773
Open Virol J. 2007 Dec 27;1:39-46. doi: 10.2174/1874357900701010039.

Human Immunodeficiency Virus (HIV) protease initiates apoptosis of HIV-infected cells by proteolytic cleavage of procaspase 8, creating a novel peptide termed casp8p41. Expression of casp8p41 alone is sufficient to initiate caspase-dependent cell death associated with mitochondrial depolarization. Since casp8p41...

Molecular and serological evidence for the presence of novel phleboviruses in sandflies from northern algeria.

The open virology journal

Moureau G, Bichaud L, Salez N, Ninove L, Hamrioui B, Belazzoug S, de Lamballerie X, Izri A, Charrel RN.
PMID: 20563287
Open Virol J. 2010 Apr 22;4:15-21. doi: 10.2174/1874357901004020015.

During summer 2007, a total of 785 phlebotomine flies were trapped in northern Algeria, identified morphologically, organised as monospecific pools and tested for the presence of phlebovirus RNA using degenerate primers. Three pools were positive, and the corresponding PCR...

The evolution of viruses in multi-host fitness landscapes.

The open virology journal

Elena SF, Agudelo-Romero P, Lalić J.
PMID: 19572052
Open Virol J. 2009 Mar 19;3:1-6. doi: 10.2174/1874357900903010001.

Provided that generalist viruses will have access to potentially unlimited hosts, the question is why most viruses specialize in few hosts. It has been suggested that selection should favor specialists because there are tradeoffs limiting the fitness of generalists...

A microarray based approach for the identification of common foodborne viruses.

The open virology journal

Ayodeji M, Kulka M, Jackson SA, Patel I, Mammel M, Cebula TA, Goswami BB.
PMID: 19718237
Open Virol J. 2009 Mar 19;3:7-20. doi: 10.2174/1874357900903010007.

An oligonucleotide array (microarray) incorporating 13,000 elements representing selected strains of hepatitis A virus (HAV), human coxsackieviruses A and B (CVA and CVB), genogroups I and II of Norovirus (NV), and human rotavirus (RV) gene segments 3,4,10, and 11...

Comparison of antiviral activity of recombinant and natural interferons against crimean-congo hemorrhagic Fever virus.

The open virology journal

Karlberg H, Lindegren G, Mirazimi A.
PMID: 20517491
Open Virol J. 2010 Apr 22;4:38-41. doi: 10.2174/1874357901004020038.

As a first line of defence against a virus infection, mammalian cells elicit an innate immune response, characterized by secretion of type I interferons (IFN) and up-regulation of interferon stimulated genes (ISGs). We have previously included Crimean Congo Hemorrhagic...

Adherence and Risk Behaviour in Patients with HIV Infection Receiving Antiretroviral Therapy in Bangkok.

The open virology journal

Clarke A, Kerr S, Honeybrook A, Cooper DA, Avihingsanon A, Duncombe C, Phanuphak P, Ruxrungtham K, Ananworanich J, Kaldor J.
PMID: 22423306
Open Virol J. 2012;6:23-8. doi: 10.2174/1874357901206010023. Epub 2012 Feb 24.

It could be postulated that due to lifestyle factors, patients with poor antiretroviral therapy (ART) adherence may also have risky sexual behaviour potentially leading to HIV transmission. There are limited data regarding unprotected sex risk and ART adherence in...

Immunotherapy of human papilloma virus induced disease.

The open virology journal

van der Burg SH.
PMID: 23341861
Open Virol J. 2012;6:257-63. doi: 10.2174/1874357901206010257. Epub 2012 Dec 28.

Immunotherapy is the generic name for treatment modalities aiming to reinforce the immune system against diseases in which the immune system plays a role. The design of an optimal immunotherapeutic treatment against chronic viruses and associated diseases requires a...

Showing 1 to 12 of 155 entries